喹诺酮类抗菌药的合理应用.pptVIP

* The first quinolone to gain any significant usage was nalidixic acid, which had a reliable activity against Enterobacteriaceae and was used for the treatment of uncomplicated urinary tract infections. Its range of activity, however, was extremely limited. The development of fluoroquinolones through the addition of a fluorine at the 6-position resulted in enhanced activity, particularly against gram-negative pathogens such as Pseudomonas aeruginosa. However, these compounds, which included ciprofloxacin, norfloxacin, and ofloxacin, continued to have only poor-to-modest activity against gram