《The effect of lipid metabolism on biological characteristics of hepatic stellate cell.》.pdf
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《The effect of lipid metabolism on biological characteristics of hepatic stellate cell.》.pdf
Availableonlineatwww.sciencedirect.com
JOURNALOF
::ScienceDirect
MEDICAL
COLLEGESOFPLA
JournalofMedicalCollegesofPLA28(2013)281-288
www.elsevier.com/locatej/mcpla
Theeffectoflipidmetabolism onbiologicalcharacteristicsof
hepaticstellatecell
JINGXinyan,YANG Xuefeng
DepartmentoftheAffiliatedNanhuaHospital,theUniversityofSouthChina,Hengyang421000,Hunan,China
ReceivedJune04,2013;acceptedSeptember20,2013
Abstract
Hepaticstellatecells(HSCs)areakindoffat—storingcells,thelipiddropletsarerichnitheCytoplasm,niwhichretinylester
accoun~for42%,triglycerideoccupies28%,cholesterol(tota1)occupies13%,phospholipidsoccupies4%respectively.Studies
haveconfirmedthatthetransformsofHSCphenotypefollowsthechangingofhtecelllipid.AfterhteactivationofHSC,with
HSC phenotypechangnigfrom aft-storingcellsnitomyofibroblast,thelipiddropletsdecreasedordisappearedgraduaUy,which
meansHSCsareunderthedifferentiatnigprocessofremovnigadipose,meawhiletriglyceride,andthemain contentoflipid
droplets,alsoobviouslyreduced.ItwaseverdeclniedthatdurnigtheprocessofHSCre—fatnig,theactivatedHSCwouldutm nito
quiescentstate.ThereforethisshowsHSCsfatmetabolism iscloselyrelatedtothebiologicalactivity
Keywords:Hepaticstellatecells;Lipidmetabolism ;Cellproliferation;Apoptosis;Liverfibrosis
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