《Therapeutic Mechanisms of Single Chinese Medicine Herb or Their Extracts for Extrahepatic Obstructive Jaundice.》.pdf

· 474· REVIEW TherapeuticMechanismsofSingleChineseMedicineHerbor TheirExtractsforExtrahepaticObstructiveJaundice ZHANGXi-ping(张喜平)’，QIUFeng-mei(仇凤梅)，andWANGXia(王 霞)。 ABSTRACT Obstructiveiaundice(OJ)isclassifiedasextrahepaticOJorintrahepaticOJ．ExtrahepaticOJis attributedtoavarietyofintricateetiologicalfactors．ResearchhasbegunwithChinesemedicine(CM)，which canbeusedasanadjunctivetherapyforextrahepaticOJ．Particularattentionhasbeenpaidtothetherapeutic effectsandtheirmechanismsofsingleCM herbandrelevantextracts．TherolesofsingleCM ortheirextracts duringadiunctivetherapyforextrahepaticOJhavebeendescribedbriefly．Thisreviewfocusesontheeffects andtheirmechanismsofrelevantherbaImedicines． KEYWORDS Chinesemedicine，extrahepaticbileduct，obstructiveiaundice，inflammatorymediators Obstructiveiaundice (OJ)ischaracterized pOsl0peratlVeIyhasbeenreportedto antagonize byagroupofcommondisordersresuItingfr0m the endotoxin productionand protectrenalfunction mechanicalstenosisorocclusionofacholangiole。biliary dependingonitsreductionofthelevelsofinterleukin。6 ductule，hepaticduct，orbilecommonductfollowedby (1L_6)，ET，andotherinflammatorymediators．。‘ thefailureofbileflow intotheduodenum．Thisblockage forcesbileintotheblood．1【JObstructionoftheextrahepatic TheeffectofSalviaeMiltiorrhizaeonalleviating bileductfr0m thehepatichilum totheduodenalpapilla iniuriestothesmalIintestinalmucosaofOJanimals isconsideredextrahepaticOJ．ExtrahepaticOJ．mainly wasshownby in Previousstudies．(8-…)Theeffect characterizedbybilirubinemiaderivedfrOm elevated wasattributedtodecreasand inhibitcalcium influx． directbilirubin．isnotan independentdiseasebuta which ameliorate the·energy supplyofhypoxic symptom ofmanydiseases．‘Thisreview discusses tissuesand celJs．Thjs majntajnscelJmembrane theeffectsandmechanismsofsingleCh