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REVIEWS
Selection of regulatory T cells in
the thymus
1 1 1,2
Chyi-Song Hsieh , Hyang-Mi Lee and Chan-Wang J. Lio
Abstract | The generation of regulatory T (TReg) cells in the thymus is crucial for immune
homeostasis and self-tolerance. Recent discoveries have revealed the cellular and molecular
mechanisms that govern the differentiation of a subset of developing thymocytes into natural
T cells. Several models, centred on the self-reactivity of the T cell receptor (TCR), have been
Reg
proposed to explain the generation of a T cell population that is cognizant of self. Several
Reg
molecular pathways link TCR and cytokine signalling with the expression of the T cell-
Reg
associated transcription factor forkhead box P3 (FOXP3). Moreover, interplay between
thymocytes and thymic antigen-presenting cells is also involved in T cell generation.
Reg
During the last decade, it has become clear that regula in tolera
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