* * Key Point Pharmacotherapies for quitting smoking include NRT and the antidepressants bupropion SR and nortriptyline. Background NRTs assist smokers in quitting by replacing nicotine that would otherwise be smoked, thereby reducing the need to smoke to obtain nicotine.1 Nicotine replacement therapy is available in many forms. Nicotine replacement gum, lozenges, sublingual tablets, inhalers and nasal spray deliver nicotine through the oral or nasal mucosa. Nicotine replacement patches, which deliver nicotine through the skin, provide a passive, longer acting system of delivery.2,3 A Cochra
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