Recent_advances_in_cancer_stem-progenitor_cell_research英文.pdf

Stem Cells Review Series J. Cell. Mol. Med. Vol 11, No 5, 2007 pp. 981-1011 Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers M. Mimeault a, d, *, R. Hauke c, d, P. P. Mehta a, d, S. K. Batra a, b, d, * a Department of Biochemistry and Molecular Biology, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA b Department of Pathology and Microbiology, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA c Division of Hematology and Oncology, Department of Internal Medicine, Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA d Eppley Institute of Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA Received: April 28, 2007; Accepted: June 29, 2007 ? Introduction ? Functions of cancer progenitor cells in the cancer initiation and progression - New model of carcinogenesis based on the cancer progenitor cells - Isolation and ex vitro and in vivo character- ization of functional properties of cancer progenitor cells - Functions of cancer progenitor cells in the cancer development - Influence of local tumour microenvironment on the behavior of cancer progenitor cells ? Cancer types originating from cancer progenitor cells - New concepts of the heterogeneity of cancers derived from distinct cancer progenitor cells - Implication of cancer progenitor cells in bone marrow-derived cancers - Leukaemias - Sarcomas - Implication of cancer progenitor cells in pediatric and adult brain tumors - Implication of cancer progenitor cells in other cancer types ? Novel cancer therapies by molecular targeting of cancer progenitor cells and their microenvironment - New concepts on the functions of cancer progenitor cells in the resistance to current cancer therapies - New combination therapies against the aggressive and recurrent