基质与内膜英文讲义.pptVIP

D. Biogenesis of Lysosomes Figure?6-23?The transport of newly synthesized lysosomal hydrolases to lysosomes.?The precursors of lysosomal hydrolases are covalently modified by the addition of mannose 6-phosphate in the CGN. They then become segregated from all other types of proteins in the TGN because a specific class of transport vesicles budding from the TGN concentrates mannose 6-phosphate-specific receptors, which bind the modified lysosomal hydrolases. These vesicles subsequently fuse with late endosomes. At the low pH of the late endosome the hydrolases dissociate from the receptors, wh