系统性红斑狼疮 SLEPPT课件.pptVIP

系统性红斑狼疮(SLE) Systemic Lupus Erythematosus SLE onset by sex and age Etiology genetic factors environmental factors Sex hormonal factors Pathogenesis Excessive, abnormal production of “self” antibodies and formation of IC. Autoantibodies against nuclear, cytoplasmic and membrane components of multiple cell types in multiple organs . Pathology 光镜:1.结缔组织的纤维蛋白样变性 2.基质黏液性水肿 3.坏死性血管炎 特征性:疣状心内膜炎 苏木紫小体 “洋葱皮样”病变 临床应用：皮肤狼疮带试验 肾活检 skin and mucosa skin and mucosa skin and mucosa skin and mucosa skin and mucosa skin and