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PEF- Ion exchange 制药工程与 及设备基础 Pharmaceutical Equipment Fundamentals .ppt
Pharmaceutical Equipment Fundamentals Ion Exchange 陈慧萍 chenhuiping@ncu.edu.cn Ion exchange Ion exchange is an exchange of ions between two electrolytes or between an electrolyte solution and a complex. denote the processes of purification, separation, and decontamination of aqueous and other ion-containing solutions with solid polymeric or mineralic 'ion exchangers'. Typical ion exchangers ion exchange resins (functionalized porous or gel polymer) Zeolites Montmorillonite Clay soil humus. Ion exchanger Ion exchange resin beads Ion exchange column used for protein purification cation exchangers that exchange positively charged ions (cations) anion exchangers that exchange negatively charged ions (anions). amphoteric exchangers that are able to exchange both cations and anions simultaneously. Typical ion exchangers However, the simultaneous exchange of cations and anions can be more efficiently performed in mixed beds that contain a mixture of anion and cation exchange resins, or passing the treated solution through several different ion exchange materials. Top 10 Biopharmaceutical Companies 1. Amgen (USA) 6. Gilead Sciences (USA) 2. Genentech (USA) 7. MedImmune (USA) 3. Serono (Switzerland) 8. Chiron (USA) 4. Biogen Idec (USA) 9. Millennium (USA) 5. Genzyme (USA) 10. InterMune (USA) ------- based on 2004 biopharmaceutical revenues Distillation Column Vertical cylindrical column Compact form Minimum ground requirements Separate stages Vaporisation and condensation Physical and chemical properties Fluid dynamics inside the unit The number of stages Overall layout of the unit Separation Technology in the Past Limits to Distillation Thermodynamics 1. Click to add Title 2. Click to add Title 3. Click to add Title 4. Click to add Title Generalized Process Scheme Materials and energy balances: conservation of energy and matter Thermodynamics: phase equilibrium and solution thermodynamics Transport phenomena Chemical reaction kinetics: rate of conve
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