临床免疫学-第1讲 自身免疫病.pdfVIP

自 身 免 疫 病 Autoimmune disease Definition •Autoimmunity: immune response against self-antigens (components) • Autoimmune disease, AID: Diseases induced by inappropriate response of the immune system against self-components •General principles: - Significant health burden, 5% of population (USA) - Multiple factors contribute to autoimmunity, - Including genetic predisposition （遗传倾向）, infections - Fundamental problem is the failure of self-tolerance •Problems: Failure to identify target antigens, heterogeneous （异质性） disease manifestations, d