中药比较药代动力学研究思路与应用宋敏_课件.pptVIP

中药比较药代动力学研究思路与应用 ;中药研究现状;中药药代动力学∈药效物质基础研究 目前，研究手段大多与化学药物相类似，针对已知活性成分单体进行研究，但单味中药即是一个化学分子库，且有效成分不甚明确，相互间可能存在的影响关系不明确。 the kava extract increased the oral bioavailability of kawain in rat which was also the main cause of the adverse drug reaction Pharmacokinetics and disposition of the kavalactone kawain:interaction with kava extract and kavalactones in vivo and invitro. Drug. Metab. Dispos. 2005, 33, 1555–1563.;中药药代动力学∈药效物质基础研究 中药中化学成分存在相互影响 The coexisting ingredients in Gentiana manshurica had remarkable influence on the pharmacokinetics of gentiopicrin Studies on pharmacokinetics of gentiopi