论文泛读课件.pptx

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论文泛读

1.Meta-analysis-胃肠病>10分(Gastroenterology,Gut,Hepatology,Journalofhepatology)在2014发表的meta分析(风险,预后,诊断…)2.Kynurenine

IncreasedIntakeofVegetables,ButNotFruit,ReducesRiskforHepatocellularCarcinoma:AMeta-analysisMethods1Databases:PubMed(Medline),WebofScience,andEMBASE2Time:from1956toMay31,20143Terms:(fruitorvegetablesordietornutritionorlifestyle)combinedwith(hepatocellularcarcinomaorlivercancerorhepatomaorlivertumor)4SelectionCriteria:a.cohortorcase-control;b.exposurewasvegetables/fruit;c.outcomewasHCCincidence/mortality;d.oddsratiosorrelativerisks(RR)with95%(CIs).Animalstudies,reviews,letters,editorials,commentaries,abstracts,unpublishedstudies,andduplicatestudieswereexcluded.5DataExtracted:firstauthor’sname,publicationyear,location,design,numberofcases,numberofcontrols,dietaryassessment,HCCdiagnosismethod,comparisons,RRswithcorresponding95%CIsforthehighestcomparedwithlowestintake,andadjustedvariables.6QualityAssessment:Newcastle-Ottawascale.Amaximumof9points.Afinalscore>6wasregardedashighquality.

StatisticalMethods1Software:STATAversion12.0.2Model:Therandom-effectsmodel3HeterogeneityAssessment:QandI2statistics,withI2>50%representingsubstantialheterogeneity.4Dose–responsemeta-analysis:GLST(Generalizedleastsquaresfortrendestimation)(atleast3quantitativecategories)5Subgroupanalysesstratifiedbypotentialconfoundingfactorsandmeta-regressionanalyseswerecarriedouttoexplorethesourcesofheterogeneity6Sensitivityanalysiswasperformedbyremovingonestudyeachtimeandexaminingtheinfluenceofaspecificstudyonthepooledresults.7PublicationbiaswasevaluatedusingafunnelplotandtheEgger’stest,withP<.1indicatingsignificantpublicationbias.“trimandfill”methodwasusedtocorrectpublicationbiasIncreasedIntakeofVegetables,ButNotFruit,Reduces

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