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小组成员：贤欢2013309110037文雅2013309110036尧咏2013309110038叶蕾蕾2013309110039AbsorptionandgutmicrobialcatabolismofPAs
4Introduction1235AbsorptioninvivoMicrobialcatabolismSummarizeStructureContent
Proanthocyanidins(PA)isakindofnaturalpolyphenols,whichiswidespreadinplantandrichinhumandiet,suchasfruits,vegetables,beverages,beansetal.Itsanimportantsecondarymetabolitesofplant,havingtheefficacyofscavengingfreeradical,anti-oxidation,anti-cardiovasculardisease,whichhasbecomearesearchhotspotinrecentyears.Generalstructureofprocyanidinsinnaturalsubstancesiscomplex.Theyaremostlyintheformofapolymerandhardtobedirectlyabsorbedbythegut,whichgreatlyreducesthebiologicalactivityofproanthocyanidins.Studyingthemetabolicprocessesofprocyanidinsinvivo,inparticularmicrobialmetabolicprocessesisofgreatmeaningtounderstanditsphysiologicalfunction.1、Introduction——
Table1PhenoliccompositionoftheVitaflavangrapeseedposition1mg/gGallicacid9.11±0.01(+)-Catechin74.6±0.09(-)-Epicatechin67.7±0.75(-)-Epicatechin-3-O-gallate26.2±0.41B161.0±1.42B245.1±0.95B320.4±0.33B415.0±0.13B2-3-O-gallate1.80±0.06B2-3-O-gallate1.61±0.01C17.07±0.08T26.81±0.06
Flavan-3-olsoccurasmonomeric,oligomeric,orpolymericforms,andthelattertwoarealsoknownasproanthocyanidinsorcondensedtannins.Mainflavanolmonomericunitsincludecatechin,epicatechin,andepicatechin-3-O-gallate.ProanthocyanidinsareconstitutedofflavanolunitslinkedbyC4?C6orC4?C8bonds.monomericunitsofPAsC4-C8bond2、Structure
Fig.1Routesfordietarypolyphenolsandtheirmetabolitesinhumans.3、Absorption3.1Routesfordietarypolyphenols
Monomericflavan-3-olsarereadilyabsorbedinthesmallintestine;dimericprocyanidinspresentlowabsorption,whereasoligomericandpolymericformsrequireactiv
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