[医学演讲专业幻灯模板推荐]SeroquelMoAnotes.pptVIP

?Neurotransmitters 2 Newer antipsychotics have a stronger affinity for the serotonin group of receptors than for the dopamine D2 receptor. This may be the reason for the minimal involuntary muscle movement side effects, as well as the low incidence of prolactin elevation and related sexual side effects observed in patients taking Seroquel, across the dose range Introduction to Seroquel The atypical antipsychotic, Seroquel, is a clever molecule with a unique receptor binding profile. Seroquel in the limbic system 1 Importantly, Seroquel has a preferential effect on the D2 receptors in the limbic region, in contrast to those located in the striatum. Since the striatum is important in controlling muscle function, this preference for limbic D2 receptors may explain why Seroquel is able to reduce the positive symptoms of schizophrenia and the symptoms of bipolar mania, while minimising the involuntary muscle movement side effects that can be so disruptive to patients’ lives. Seroquel in the limbic system 2 In the limbic region Seroquel blocks both the D2 and 5HT2A receptors. But unlike in the striatum, this blocking of the 5HT2A receptors does not trigger the release of more dopamine. Dopamine in the limbic system and striatum There are also important differences in the way in which dopamine is released in the striatum and the limbic system. Seroquel in the striatum 1 More dopamine is released in the striatum than in the limbic system. In the striatum, Seroquel binds to the dopamine D2 receptors. In addition, Seroquel binds to the 5HT2A receptor, which triggers the release of more dopamine in the striatum. Seroquel in the striatum 2 The release of so much dopamine displaces the Seroquel from the D2 binding site, allowing dopamine to bind. Seroquel in the striatum 3 Since it is the blockade of the dopamine receptors in the striatum that is the cause of the involuntary muscle movement side effects, Seroquel’s clever mechanism of action allows dopamine to mainta