干细胞移植治疗弥漫大B细胞淋巴瘤.pdf

Hematopoietic Stem Cell Transplantation for Diffuse Large B-cell Lymphoma Philip J. Bierman, M.D. March 23, 2012 Indications for Hematopoietic Stem Cell Transplants in Indications for Hematopoietic Stem Cell Transplants in the United States, 2009 the United States, 2009 5,500 Allogeneic (Total N=7,012) 5,000 Autologous (Total N=9,778) 4,500 4,000 3,500 3,000 2,500 2,000 1,500 1,000 500 0 Multiple NHL AML HD ALL MDS/MPD Aplastic CML Other Non- Other Myeloma Anemia Leuk Malig Cancer CIBMTR Disease Parma Study for Relapsed Parma Study for Relapsed Intermediate- and High-Grade NHL Intermediate- and High-Grade NHL Bone marrow harvest BEAC ABMT ±RT Sensitive D D st nd H H DHAP 1 or 2 Salvage Tx relapse A A ±RT ABMT P P Resistant N Engl J Med 333:1540-1545, 1995 PARMA Trial: ABMT vs. Conventional Treatment 100 90 P = 0.001 80 70 ) % 60 ( l