生物鉴别物存在的基于模式分裂光学生物传感.docVIP

  Biorecognition-presented detection in mode-splitting-based biosensing#  5 10 15 20 25 30 35 40 Yi Xu, Xiao Yunfeng, Feng Yin, Qiu Dongyin, Fan Jingyi, Li Yan, Gong Qihuang** (School of Physics, Peking University, Beijing 100871) Abstract: A pair of counter-propagating high-Q whispering-gallery modes (WGMs) can couple to each other and produce two new standing modes with a significant resonance splitting when single or multi-scatterer are on the cavity surface. In this paper, we theoretically investigate the mode-splitting-based biosensing by using a biorecognition-covered WGM microcavity because the pre-covering is essentially necessary for label-free detection of specific biological targets. It is shown that the minimum size of biological target suitable for detection is subjected to the surface pre-covering ratio. We further propose a simple scheme for concentration detection by applying the total linewidth broadening of the two standing modes. Unlike the conventional signal by using the mode splitting itself, here the total linewidth broadening is not only immune to thermal fluctuation, but also linear with the target nanoparticle concentration in dilute solution. The relative standard error of the total broadening signal is also scrutinized. Keywords: optics; whispering gallery mode; biosensing 0 Introduction Label-free optical biosensors based on microresonators have attracted much attention over the past few years because they are crucial to biomedical research, healthcare, pharmaceuticals, environmental monitoring, and homeland security [1-10]. Among them, microresonators which support whispering-gallery modes (WGMs) are of special interests owing to their ultra-high Q-factors, small mode volumes and ease for mass production on a chip. Ultrahigh-sensitivity detection down to single molecule has been achieved through monitoring the shift of resonance frequency induced by biomolecules adsorbed on the resonator surface [11-12]. Unfortunately, this detecti