静电纺丝制备肌腱组织工程支架的研究进展.docVIP

中国修复重建外科杂志2012年7月第26卷第7期 静电纺丝制备肌腱组织工程支架的研究进展 谭敬豪李敏  ·865·  【摘 要】  目的  综述静电纺丝（简称电纺）技术在肌腱组织工程支架制备方面的应用，描述其应用效果及前 景。 方法 查阅近年来国内外应用电纺技术制备肌腱组织工程支架的相关文献，并从多方面进行阐述。 结果 电纺 技术制得的电纺纤维，因其大比表面积和高孔隙率，近年来广泛用于肌腱组织工程支架材料的研究。包括聚乳酸在内的 多种材料已成功电纺成各种类型的肌腱组织工程支架，并在肌腱缺损修复中取得良好效果。 结论 电纺技术为肌腱组 织工程支架材料的制备提供了新途径，随着该技术的完善，其将会在肌腱组织工程领域拥有广阔的应用前景。 【关键词】 静电纺丝 肌腱组织工程 支架材料  ADVANCES OF RESEARCH ON PREPARATION OF TENDON TISSUE ENGINEERED SCAFFOLDS USING ELECTROSPINNING/TAN Jinghao, LI Min. College of Life Sciences, Fujian Normal University, Fuzhou Fujian, 350108, P.R.China. Corresponding author: LI Min, E-mail: mli@ 【Abstract】 Objective To review the appl ication of electrospinning in preparation of tendon tissue engineered scaffolds, to describe its appl ication effect and prospects. Methods Recent l iterature was extensively reviewed and summarized from various aspects, concerning the appl ication of electrospinning in preparing tendon tissue engineered scaffolds. Results Because of its huge surface and high porosity, the electrospun fibers prepared by electrospinning technology have been widely used in the manufacture of tendon tissue engineered scaffolds in recent years. A variety of materials, including polylactic acid, have been successfully electrospun into various types of tendon tissue engineered scaffolds, and good results in the repair of tendon defect were achieved. Conclusion The electrospinning technology has provide a new way for the preparation of the tendon tissue engineered scaffolds, with the perfection of the technology they will have broad appl ication prospects in the field of tendon tissue engineering. 【Key words】 Electrospinning Tendon tissue engineering Scaffold material Foundation item: Key Planning Project of Science and Technology of Fujian Province (2010Y0020)  肌腱是肌腹两端的索状或膜状致密结缔组织，便 [1] 腱缺损，由于肌腱组织自身修复能力有限，缺损后往往 不能自行修复。美国每年报道的肌肉与骨骼损伤中， 有 50% 涉及肌腱和韧带的软组织损伤，而且常因治疗 不及时导致患者受损肌腱的功能恢复不全或完全丧 失 [2-3]。目前，肌腱损伤的修复方法主要有自体肌腱移 植、异种肌腱移植、人工肌腱替代等。除了