阿立哌唑与氟哌啶醇治疗难治性精神分裂症的对比研究.pdfVIP

NervousDiseasesandMentalHeahh。2006，V01．6，No．1 ·学术交流· 阿立哌唑与氟哌啶醇治疗难治性精神分裂症 的对照研究 王立钢 王东明 孙艳 【摘要】 目的 比较阿立哌唑与氟哌啶醇治疗难治性精神分裂症的疗效。方法 78例符合入组 条件的难治性精神分裂症病人，随机分2组，分别应用阿立哌唑或氟哌啶醇治疗1z周，应用阳性和阴性 阿立哌唑组总有效率为61．54％， 症状量表(PANSS)和副反应量表(TESS)评定疗效和副反应。结果 明显高于氟哌啶醇组的43．59％。2组间在PANSS总分，阴性症状量表分及一般病理症状量表分值方 面的差异具有显著性意义(P0．01)。结论阿立哌唑对难治性精神分裂症的疗效优于氟哌啶醇，对 阴性症状的效果尤其明显。 【关键词】阿立哌唑； 氟哌啶醇；精神分裂 with A of and inthetreatmentof treatment--resistant studyariplprazolehaloperldol patient comparative WANG Yah．TheMentalHealthCenter schizophreniaLi-gang，WANGDong-ming，SU of 266034，凸ina Tsingdao，Tsingdao andsideeffectsof and on To the haloperidol [Abstract]Objectivecompareefficacy aripiprazole withtreatment——resistant 78 withthe of patients schizophrenia．Methodspatients diagnosis were to or treatmentfor12 treatment--resistant hatoperidol schizophreniarandomlyassignedaripiprazole andsideeffectsweremeasuredwithPANSSandTESS．ResultsTheoverall weeks．Efficacy therapeu— tothatof werestatistical ticeffectof superior haloperidol(43．59％)．There aripiprazole(61．54％)was differencesinthePANSStotalscoresandNorGscalescoresbetweenthetwo groups(P0．01)． Conclusions is to inthetreatment--resistant Aripiprazolesuperiorhaloperidol schizophrenia，especially to symptoms． negative schizophrenia [Keywords]Aripiprazole；Haloperidol；Treatment--resistant 中图分类号：R