心理应激前后血液中部分血管活性物质浓度的变化.pdfVIP

·148 · Chinese Journal of Behavioral Medi cal Science 12( 2) ,2003 基础研究·论著 心理应激前后血液 中部分血管活性物质浓度的变化 陈新, 赵英, 何爱桃, 杨露青, 李凤华 ( 南华大学公共卫生学院流行病学教研室, 衡阳 421001) 摘要: 目的 探讨不 同行为类型者心理应激时血液中血管活性物质浓度的变化。方法 以健康的男大学生49 人为研究 对象, 用速算 比赛使其产生心理应激, 比较不 同行为类型者心理应激前后的血压、血浆血管紧张素 Ⅱ( Ang Ⅱ) 、醛 固酮( ALD) 、 心钠素( A NP) 及血清一氧化氮( NO) 浓度的变化。结果 心理应激后血压、血浆Ang Ⅱ、ALD 的浓度较心理应激前增加( P 0 .05) , 且 A 型行为类型者舒张压、血浆Ang Ⅱ、ALD 浓度的增幅较非A 型行为类型者大( P 0 .05) ; 应激后血清 NO 浓度下 降( P 0 .00 1) , 且应激前后血清 NO 浓度的变化A 型行为类型者较非 A 型行为类型者更为明显( P 0 .05) ; 心理应激前后 血浆ANP 浓度无改变。结论 心理应激所致 的血压 升高可 能既与缩 血管物质浓度的增加有关, 同时也 与 NO 浓度 减少有 关。 关键词: 心理应激; 血管紧张素 Ⅱ; 醛 固酮; 心钠素; NO The effect of laboratory mental stress on plasma levels of angiotensin Ⅱ, aldosterone, atrial natriuretic peptide and NO CHE N Xi n , ZHAO Yi n g , HE Ai-t ao , et al . Depar t ment of Epi de mi ol ogy , Nanhu a Uni ver sit y , Hengya ng , Hu n an 421001 Abstract : Obj ective To st udy the effect of laboratory mental stress on pl as ma l evels of angiotensi n Ⅱ( Ang Ⅱ) ,al dosterone ( ALD) , atrial natriuretic peptide ( ANP) and NO i n healthy subj ects wit h different type of behavior . Methods Blood pressure , plas ma Ang Ⅱ, ALD and ANP concentrati on and t he level of serum NO were observed before and after mental arit hmetic test . Re- sults Levels of Blood pressure , plas ma Ang Ⅱand ALDi ncreased si gnificantly ( P 0 .05) and the level of serum NO decreased sig- nificantly ( P 0 .001) duri ng mental arit hmetic test . changi ng val ues of l evels of di astolic pressure , pl as ma Ang Ⅱand ALD and seru m NO concentration were greater i n t he students of type A behavior pattern(