脂质体运用于胰岛素口服给药治疗糖尿病的可能性外文翻译.doc

POSSIBILITY OF THE USE OF LIPOSOMES FOR ORAL ADMINISTRATION OF INSULIN IN DIABETES MELLITUS Insulin is secreted by pancreatic cells of vertebrate peptide hormones, hypoglycemic have a unique effect, so far remains the drug of choice of insulin-dependent diabetes. Because it is easy to gastrointestinal proteolytic enzymes degrade the oral invalid. Insulin injections are currently the most effective agents for the treatment of diabetes, usually after sc or im, its main drawback is slow to absorb the injection site, long-term injection will bring a lot of pain and inconvenience to the patient, and even inflammation, induration, allergies and other side effects. Research and easy to use, effective, safe and reliable insulin formulation is new domestic and international pharmaceutical industry issues of common concern. Liposomes are targeted drug carriers are targeted delivery system, the same components with the cell membrane phospholipids, drugs are encapsulated within a phospholipid bilayer, can enhance the stability of drugs, a large number of suitable encapsulation easy to be damaged such polypeptide drug molecules, and its high compatibility biofilm, can promote the absorption of drugs, the drug through the lipid bilayer slow controlled release, sustained release may play a role. Liposomes can be made ??into various particle sizes, by changing the composition of the phospholipid liposomes that may have different surface properties, and therefore suitable for various routes of administration. Exists as a dimer of insulin molecule is a hydrophobic inner core consisting of a non-polar side chains, the entire outer surface of the polar side chain distribution, the structural characteristics of the hydrophilic surface, a hydrophobic core. Liposome bilayer membrane, and its structure is characterized by a hydrophilic surface, the internal hydrophobic bilayer Insulin molecule having a hydrophilic surface groups, it is difficult within the liposome through a hydrophobic