罗格列酮对2型糖尿病患者C反应蛋白的影响.DOCVIP

临床医学论文-罗格列酮对2型糖尿病患者C反应蛋白的影响 【摘要】? 目的 探讨罗格列酮对2型糖尿病患者C反应蛋白水平的影响。 方法 将40例2型糖尿病患者随机分为研究组26例，对照组14例。两组均在饮食控制、运动疗法的基础上，口服降糖药物治疗。研究组联合罗格列酮治疗。观察12 w。于治疗前后测定两组患者的糖化血红蛋白、空腹血糖、空腹胰岛素、甘油三脂、胆固醇、C反应蛋白，计算胰岛素抵抗指数，对两组测定结果进行对比分析。 结果 治疗12 w末，研究组糖化血红蛋白、空腹血糖、空腹胰岛素、C反应蛋白及胰岛素抵抗指数均较治疗前有显著下降（P＜0.01）；甘油三脂及胆固醇虽有所下降，但差异无显著性（P＞0.05）。对照组各项生化指标虽较治疗前有所下降，但差异均无显著性（P＞0.05）。两组间比较研究组C反应蛋白水平较对照组下降显著（P＜0.01）。 结论 罗格列酮治疗2型糖尿病，不仅能提高患者的胰岛素敏感性，改善胰岛素抵抗显著降低血糖，而且可显著降低血浆C反应蛋白水平，为预防糖尿病及其并发症提供了新的前景。 【关键词】? 2型糖尿病；C反应蛋白；罗格列酮 　　Effects of rosiglitazone on Creactive protein of patients with type 2 diabetes 　　【Abstract】 Objective? To explore the effects of rosiglitazone on Creactive protein of patients with type 2 diabetes. Methods? 40 patients with type 2 diabetes were randomly divided into research（n=26） and control group（n=14）. The two groups took oral blood glucose lowering drugs based on alimentary control and exercise therapy，the research group was plus rosiglitazone，for 12 weeks. Before treatment，such indexes were measured and compared as glycosylated hemoglobin，bloodfasting sugar，fasting insulin，triglyceride，cholesterol，Creactive protein，and insulin resistance indexes accounted. Results? At the end of the 12th week，glycosylated hemoglobin，bloodfasting sugar，fasting insulin and Creactive protein all lowered more significantly in the research group compared with pretreatment（P0.01），although triglyceride and cholesterol did to some extent，there were no significant differences（P0.05）. All biochemical indicators lowered to some extent compared with pretreatment in the control group，but differences were not significant（P0.05）. Levels of the Creactive protein lowered more significantly in the research than in the control group（P0.01）. Conclusion? Rosiglitazone not only increases patients’ insulin sensitivity，improves insulin resistance and reduces blood glucose significantly，but also reduces plasma Creactive protein levels and provides new prospect for preventing diabetes and complications. 　　【Keyword