TIA患者颈动脉硬化与溶血磷脂酸、D-二聚体的相关性研究.docVIP

TIA患者颈动脉硬化与溶血磷脂酸、D-二聚体的相关性研究 安学林 王卫胜 山东省聊城市第三人民医院 邮编：252000 E-mail 摘要 目的：探讨TIA患者颈动脉粥样硬化与溶血磷脂酸、D-二聚体的相关性。方法：选择196例TIA患者，同时选择120例健康者作为对照组。由同一B超医生进行颈动脉超声检查，观察颈动脉内膜厚度、回声强度，观察颈动脉有无斑块，斑块的部位、形状、大小及表面是否有溃疡等。结果：TIA患者组的溶血磷脂酸、D-二聚体水平均显著高于健康者组，二者差异有显著性(P＜0.05)，伴随着颈动脉粥样硬化的严重程度的增加，水平有逐渐增加的趋势；通过不同斑块性质的比较发现，各组间溶血磷脂酸、D-二聚体水平均有显著差异性(P＜0.05)，且D-二聚体水平与斑块的稳定性有关。结论：颈动脉粥样硬化的发生与溶血磷脂酸、D-二聚体水平有相关性，颈动脉粥样硬化的程度与溶血磷脂酸、D-二聚体水平有相关性，溶血磷脂酸、D-二聚体水平在一定程度上可反映颈动脉粥样硬化的进展情况。 关键词：TIA；颈动脉粥样硬化 溶血磷脂酸 D-二聚体 The study in the correlation with carotid atherosclerosis of the TIA patients and lysophosphatidic acid, the D-dimer Abstract Objective: Explore the correlation with carotid atherosclerosis of the TIA patients and lysophosphatidic acid, the D-dimer. Methods: Choose the 196 cases of the TIA patients, and choose the 120 cases of healthy persons as control group. Carotid ultrasound examination operated by the same ultrasound doctor, and observe the intima-media thickness of carotid artery and echo intensity，observe with or without plaque of carotid artery, and plaque location, shape, size and surface whether there is ulcers. Results: The levels of lysophosphatidic acid, D-dimer with TIA patients are significantly higher than the healthy group, the difference is significant(P0.05), and accompanied by the increase in the severity of carotid atherosclerosis, its levels have a growing trend. By comparison of the different nature of plaque, the levels of lysophosphatidic acid, D-dimer among the groups are significant differences(P0.05), and the levels of D-dimer levels related with the stability of the plaque. Conclusion: The levels of lysophosphatidic acid and D-dimer relate the occurrence with carotid atherosclerosis; The levels of lysophosphatidic acid and D-dimer relate the extent with carotid atherosclerosis; To a certain extent，the levels of lysophosphatidic acid and D-dimer can reflect the progress of carotid atherosclerosis. Key words: TIA carotid atherosclerosis lysophosphatidic acid D