Meta分析中发表偏倚的Beggs检验、Eggers检验及Macaskills.pdfVIP

Methodology Chin J Evid-based Med 2009, 9(8): 910-916 Meta分析中发表偏倚的Begg’s检验、Egger’s检验 及Macaskill’s检验的SAS程序实现 1, 2 3 1,* 郑辉烈   王忠旭  王增珍 1. 华中科技大学同济医学院公共卫生学院流行病与卫生统计系（武汉 430030 ） 2. 南昌大学医学院公共卫生学院流行病与卫生统计系（南昌 330006 ）；3. 中国疾病预防控制中心（北京 100050 ） 摘要 Meta 分析的结论易受各种偏倚的影响，“发表偏倚”是其中重要的偏倚之一。所以，评价所纳入的研究 是否存在发表偏倚是Meta 分析的一项重要的前期准备工作。Begg’s 检验、Egger’s 检验和Macaskill’s 检验是常见的 用于定量评价Meta 分析“发表偏倚”的方法，为了便于这些检验方法的应用，本文编写了基于SAS 系统的这三个 检验的程序，经实例数据分析，其运行结果与Stata 软件完全相同。为研究人员提供了同时实现这三个检验的有效 途径。 关键词  Meta 分析；发表偏倚；Begg’s 检验；Egger’s 检验；Macaskill’s 检验 Applying the SAS Program to the Complete Begg’s Test, the Egger’sTest, and the Macaskill’s Test for Publication Bias of Meta-analysis 1,2 3 1,* ZHENG Hui-lie , WANG Zhong-xu , WANG Zeng-zhen 1. Department of Epidemiology and Statistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China 2. Department of Epidemiology and Statistics, School of Public Health, Medical College of Nanchang University, Nanchang 330006, China 3. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China Abstract The conclusions of meta-analyses are susceptible to various of biases, and publication bias is one of such main bias. Therefore, Checking for evidence of publication bias should be undertaken routinely at the preliminary stage of a meta-analysis. Begg’s test, Egger’s test, and Macaskill’s test are usually used to objectively identify publication bias in meta-analyses. In order to conveniently use these methods, the SAS program of these three tests was designed in this paper. In order test practical data, the fact that the output of this program of SAS software was consisted with the output of STATA software was validated. So, this prog