Toll样受体4及其调控神经病理性痛的可能机制.pdfVIP

第25卷第9期 生命科学 Vol. 25, No. 9 2013年9月 Chinese Bulletin of Life Sciences Sep., 2013 文章编号：1004-0374(2013)09-0932-05 Toll 4 样受体 及其调控神经病理性痛的可能机制 阮丽钦，洪炎国* (福建师范大学生命科学学院，生物学和神经科学省级重点实验室，福州 350108) Toll 4 Toll-like receptor 4, TLR4 摘　要： 样受体 ( ) 是一类介导固有免疫的跨膜信号转导受体，近来有研究发 现TLR4 不仅是参与机体免疫应答的重要蛋白，而且能识别伤害性刺激，诱导一系列神经活性物质和促炎 因子的释放，激活胶质细胞，最终导致炎症和神经病理性痛的产生和维持。主要通过对TLR4 的生物学结构、 TLR4 功能发挥依赖的相关分子以及TLR4 介导神经病理性痛的可能通路进行综述，阐述TLR4 在神经病理 性痛的发生和发展中的作用。 Toll 4 关键词： 样受体 ；神经病理性痛 ；胶质细胞 Q422 R338 A 中图分类号： ； 文献标志码 ： Toll-like receptor 4 and the possible mechanism underlying TLR4 mediated neuropathic pain RUAN Li-Qin, HONG Yan-Guo* (Key Laboratory of Developmental Biology and Neuroscience in Fujian Province, College of Life Science, Fujian Normal University, Fuzhou 350108, China) Abstract: Toll-like receptor 4 (TLR4) is a type of transmembrane signal transduction receptors, which mediate innate immune respones. Recently, studies have found that TLR4 is not only an important protein involved in the body immune response, but also able to induce the release of neuroactive substances and pro-inflammatory cytokines by activating glial cells following noxious stimuli, which eventually contributes to inflammation and neuropathic pain. This article briefly describes the TLR4 structure and its biological function, as well as TLR4 function-related molecules. Furthermore, the role of TLR4 in neuropathic pain and the mechanism underlying TLR4 mediation of neuropathic pain are discussed.