·实验研究·CompoundK注射液免疫毒性评价.pdfVIP

国际中医中药杂志2013年9月第35卷第9期 Int J Trad Chin Med, September 2013, Vol. 35, No.9 ·789 · ·实验研究 · 人参皂苷 Compound K 注射液 免疫毒性评价 宋超 董鲁平 李淑珍 【摘要】 目的 评价人参皂苷 Compound K 注射液的免疫毒性。方法 采用主动全身过敏试验、被 动皮肤过敏试验对人参皂苷 Compound K 注射液的免疫毒性进行评价。结果 主动全身过敏试验中，阳性 对照过敏反应呈极强阳性，人参皂苷 Compound K 注射液的高、低剂量组均未见过敏反应，各组豚鼠的体 重变化未见明显差异。被动皮肤过敏试验中，阳性对照组各动物均出现蓝斑，且直径＞5 mm，左侧蓝斑直 径（10.1±3.34 ）mm ，右侧蓝斑直径（7.57 ±1.94）mm ，血清 IgE 含量明显增高（P ＜0.01 ），人参皂苷 Compound K 注射液的高、低剂量组均未出现直径＞5 mm 的蓝斑，血清 IgE 含量未见明显改变。结论 人参皂苷 Compound K 注射液在该实验条件下未见免疫毒性。 【关键词】 人参皂苷 Compound K 注射液；主动全身过敏试验；被动皮肤过敏试验 Immunotoxicity study of Ginenoside Compound K Injection SONG Chao, DONG Lu-ping, LI Shu-zhen. Pharmacy department of Shandong Jiaotong hospital, Shandong 250031, China Corresponding author：SONG Chao, Email ：Chaosong@yahoo.cn 【Abstract 】 Objective Evaluate the immunotoxicity of Ginenoside Compound K Injection. Methods Active Systemic Anaphylaxis (ASA)tests and Passive Cutaneous Anaphylaxis (PCA)tests were used to evaluate Ginenoside Compound K Injection. Results In the ASA tests, positive control group showed pole-strength anaphylaxis, both the high-dose group and the low-dose group of Ginenoside Compound K Injection didn’t produce allergic reaction and the body weights of all groups showed no significant differences. In the PCA tests, all rats of positive control group caused blue spots with their diameters bigger than 5 mm (diameters on the left side of blue spots was (10.1±3.34)mm and diameters on the right side of blue spots was (7.57 ±1.94)mm. Serum IgE was significantly increased. While both high dose and low dose of Ginenoside Compound K Injection group didn’t show blue spots with their diameters greater than 5 mm and their IgE levels showed no significant differences compared wi