以胆酸为核的星型聚(D,L-乳酸)药物缓释材料的直接熔融聚合法制备与表征.pdfVIP

《化学通报》在线预览版 以胆酸为核的星型聚(D,L-乳酸)药物缓释材料的直接熔融聚合 法制备与表征 赵海军 汪朝阳* 侯晓娜 罗玉芬 毛郑州 (华南师范大学化学与环境学院化学系 广州 510006) 摘 要 直接以廉价的外消旋乳酸(D,L-LA)为原料，胆酸为核，氧化亚锡为催化剂，采用熔融聚合法 合成了星型结构的胆酸-聚(D,L-乳酸)共聚物，分别考察预聚时间、催化剂种类、用量以及熔融共聚时间等 的影响，并用FTIR 、1H NMR 、GPC 等进行表征。当胆酸和乳酸的投料比(物质的量)为 1:64、预聚 8h、熔 融共聚 8h、熔融温度 160℃、催化剂用量 0.3%时，以 51.9%的产率生成了重均分子量(Mw)达 5600(分散度 Mw/Mn = 1.37) 的共聚物。系统分析表明，每个星型结构的高分子含有一个胆酸单元核心。方法步骤少、路 线简捷，有利于该类含特殊功能基团的药物缓释材料的廉价、快速合成。 关键词 外消旋乳酸 胆酸-聚(D,L-乳酸)共聚物 熔融聚合 星型高分子 药物缓释材料 Direct Synthesis of Star-shaped Poly(D,L-lactide-cholicate) via Melt Copolycondensation and its Characterization Zhao Haijun, Wang Zhaoyang, Hou Xiaona, Luo Yufen, Mao Zhengzhou (Department of Chemistry, South China Normal University, Guangzhou 510006) Abstract Using cheap D,L-Lactic acid (D,L-LA) as raw material, cholic acid as a core, and SnO as a catalyst, star-shaped poly(D,L-lactide-cholicate) was directly synthesized via melt copolycondensation. The 1 copolymer was characterized with FTIR, H NMR, DSC and GPC. The optimal synthetic conditions, including prepolymerization time, kinds of catalysts, dosage of catalysts and polymerization time, were discussed in detail. When catalyzed by 0.3% SnO under the condition of feed molar ratio of cholic acid to lactic acid 1׃64, reaction temperature 160 ℃, prepolymerization time 8h and successive polymerization time 8h the copolymer with weight-average molecular weight (Mw) of the copolymer was 5600 (Mw/Mn=1.37) was obtained the yield 51.9%. The characterization indicated that every star-shaped copolymer molecule embedded one cholic acid cell as the core. The direct copolycondensation method was a cheap and