药物有效性癫痫与难治性癫痫患者自杀风险的比较研究.pdfVIP

浙江医学2014 年第36 卷第9 期 药物有效性癫痫与难治性癫痫 患 自杀风险的比较研究 陈哲萌 郭谊 丁美萍 （ 。 【摘要 】 目的 比较成年药物有效性癫痫（DR-EP ）与难治性癫痫 DNR-EP ）患 抑郁障碍和自杀风险的发生率 方法 （ 采用简明国际神经精神访谈 MINI ）中的抑郁障碍和自杀模块对43 例DR-EP 患 和51 例 DNR-EP 患 进行抑郁障碍及自杀风险 、初次发病年龄、病 比较两组 评估，并详细记录患 年龄、性别、就业状态、婚姻状态、教育年限 程、癫痫发作类型和抗癫痫药物种数， 抑 。 郁障碍与自杀风险的发生率 结果 DR-EP 组中抑郁障碍23.3% ，自杀风险27.9%。而DNR-EP 组中抑郁障碍23.5% ，自杀风险 （ 21.6%。两组抑郁障碍与自杀风险的比例均无统计学差异 均P ＞0.05 ）。结论 DR-EP 与DNR-EP 患 抑郁障碍与自杀风险的 。 ，以利 发生率并无差异 DR-EP 患 也需要进行抑郁障碍和自杀风险的评估 于及时干预。 【关键词】 药物有效性癫痫 药物难治性癫痫 抑郁障碍 自杀风险 简明国际神经精神访谈 Depression and suicide risks in drug-responsive epilepsy versus drug non-responsive epilepsy China 【Abstract 】 Objective To compare the depression and suicide risks in patients with drug-responsive epilepsy (DR-EP) and those with drug non-responsive epilepsy (DNR-EP). Methods Forty three patients with drug-responsive epilepsy and fifty one patients with drug non-responsive epilepsy from the Second Affiliated Hospital, Zhejiang University School of Medicine were enrolled in the study. The depression and suicide risks were evaluated by using the depression and suicide module of the Mini International Neuropsychiatric Interview (MINI). Variables including age, gender, employment status, marital status, years of edu- cation, onset age of seizure, epilepsy duration, types of seizure, types of antiepileptic drugs were documented. The rates of de- pression and suicide risk were compared between two groups. Re