222例氟喹诺酮类抗菌药物致不良反应报告分析.pdfVIP

222例氟喹诺酮类抗菌药物致不良反应报告分析 医院，北京100050) 中图分类号R978．1 文献标识码B 文章编号1672—2124(2011)06—0563—03 摘 要 目的：调查氟喹诺酮类抗茵药物不良反应的特点，为临床合理用药提供依据。方法：检索1979--2010年医学文献中收栽 的氟喹诺酮类抗茵药物不良反应的资料222例，对氟喹诺酮类抗茵药物的用法用量、不良反应发生的时间和临床特点进行分析。 药43例。未知3例。结论：氟喹诺酮类抗菌药物不良反应的发生与患者的年龄、原患疾病、药物过敏史及联合用药等相关因素有 关。 关键词 氟喹诺酮类抗茵药物；不良反应；合理用药 Antibacterial Adverse of222Cases Agents-inducedDrugReactions：Analysis Fluoroquinolone LU District HealthService Xiu—ling。，ZHAOZhi—gan94(1．BeijingChaoyangSanjianfangCommunity Tiantan Affiliatedto Medical 100024，China；2．BeijingHospital Capital University， Center，Beijing 100050，China) Beijing ABSTRACT thecharacteristicsof antibacterial adverse OBJECTIVE：To nuoroquinolone study agents．induceddrug orderto referencesforclinicalrationaluse．METHODS：Atotalof222casesof reactions(ADR)in provide drug in 1979and2010were antibacterial ADRindexedmedicalliteraturebetween collected fluoroquinoloneagents．induced for the andadministrationof antibacterial toADRonsetand analysis dosage fluoroquinoloneagents，time regarding ofthe thetotal222 weremalesversus108 clinicalcharacteristicsADR．RESULTS：Ofcases。113 females；181 received antibacterialaloneand41 received antibacterialincombination nuoroquinoloneagents nuoroquinoloneagents withother 73received antibacterial intravenousinfusionand43 oral drugs；1 fluoroquinolone agentsby by administration．andtheroutesofadministrationin3 casesremained antibacterial adve