产超广谱β-内酰胺酶细菌尿路感染危险因素及耐药性分析.pdfVIP

产超广谱p一内酰胺酶细菌尿路 感染危险因素及耐药性分析 谢一潋褚金国 钱国清李国祥 【摘要】 目的分析尿路感染患者感染产超广谱p一内酰胺酶(ESBLs)细菌的危险因素及药敏试验结果，以指导临床治疗。 测定培养菌株的耐药性。结果单因素分析发现，男性、尿路梗阻、尿路置管、最近1年内发作3次以上尿路感染、最近3个月内用过 1 10～10．866，PO．01)、最近3个月内用过B一内酰胺类抗生素(0尺=10726，95％Cl=3 ESBLs细菌仅对亚胺培南、美罗培南、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦、阿米卡星保持较低耐药率。结论根据危险因素早期 识别感染产ESBLs细菌的高危人群，有利于尽早选用合适的抗生素，提高治疗有效率。 【关键词】 尿路感染超广谱B一内酰胺酶危险因素耐药性 bacteria from with tractinfectionX膳 Riskfactorsand resistanceof isolated drug extended—spectrump—Iactamasepos…ve patientsurinary of|ntectious FIrst Y№n．CHuJinguo．QlANGuoqIn9，eta1．Departmem Disease，NingboMunicjpalHosp㈦．Ⅻngbo315000．Chlna 【Abstract】 To theriskfactorsand resistanceofextended—spectrumD～iactamasepos．tiVite Objectiveinvestigate drug from with tractinfection．MethodsThecIinicaldataof64 with tractin— bacteria(ESBLs)jsoIatedpatientsurinary patientsurinary fectionscaused E§cher『c_h妇co|iand，(／ebs，ef／a frOm 2012tODec2013inOur byESBLs—prOducing p几eumo几国eJuly hOspital six with fractinfectionscaused Esc，1e，忙hjacoIiand，(／ebsfef／a were by p几eu— anaIyzed．Ninetypatlentsurinary ESBLs—negatiVe were contrOIsK—Bme廿10dwasusedtodetectresistanceto monjaeadmittedinthesameperiOdenrO||edas drug Results revealedthaC nivariate andmultivariate wereusedfOrstatisticaI Univariate analysis IOgisticregressiOn analysis． anaIysis withtheinfectiOncaused bacteriaweremaIe tract fivefactorsassOciated byESBLs—prOducing gender，urinary