转化医学：让中药现代化又快又好走进临床.pdfVIP

转化医学：让中药现代化又快又好走进临床 肖小河* 王伽伯 鄢丹 （解放军 302 医院全军中医药研究所 北京 100039） [摘要] 国家大力推进中药现代化取得了重要成就已为中药学人的共识，然而 临床医生和广大老百姓对中药现代化成果的感受仍较为滞后，甚至感受不多。重 视临床、结合临床，大力开展中药转化医学研究，是推动中药现代化走进临床的 重要出路和举措。中药转化医学研究路径可概括为：源于临床-证于实验-回归临 床的循环往复过程；其研究内容可概括为：面向临床的中药标准化研究和源于临 床的创新中药研制。面向临床的中药标准化研究的核心，是以临床需求为导向， 建立以功效为基础的中药品质与性效评价方法和标准，推动中药 “品-质-性-效- 用”一体化，使中药标准在临床上能让医生看得懂、用得上；源于临床的创新中 药研制，包括基于临床经验和循证医学证据的特色复方中药研制、基于临床标本 和组学方法的现代组分中药研制，加快中药新药研究与开发进程，为中医临床提 供“源于传统，优于传统”的安全高效药物。建议国家有关主管部门从科研立项、 人才培养、新药审评及配套的相关政策法规和组织机构等方面，支持中医药转化 医学研究工作。 [关键词] 转化医学；中药现代化；新药开发；合理用药；品质性效用一体化 Translational Medicine: Promoting TCM Modernization into Clinic XIAO Xiao-he*, WANG Jia-bo, YAN Dan, (China Military Institute of Chinese Medicine, 302 Military Hospital， Beijing 100039) Abstract: The government’s vigorous advance on modernization of traditional Chinese medicine (TCM) has achieved great successes, which are the consensus of scholars. However, the physicians and populace have little awareness of the TCM modernization achievements. It is great need to promote the modernization of TCM into clinic by translational medicine. The research pathway of TCM translational medicine could be summarized as a repeated cycle of bedside to bench to bedside (B2B2B). And, its main research might include two missions, one is the clinic-oriented standardization of TCM and the other is the clinic-derived discovery of TCM new drugs. The clinic-oriented standardization of TCM is focusing on the development of the effect-based evaluating methods and standards on TCM quality and drug property, which aims at making doctors