微混合器溶析沉淀与静电喷雾干燥一体化可控制备药物纳米颗粒.pdfVIP

0 40% [1] [2] [3] Ostawld [4] [5] 1100 μm 1 [6] [7] ≥99% 25 °C 0.9 μS/cm 1 1184 μm400 μmDW-P103-10ACE1 ZetaPLAS JSM 7401 JEEOL 3 3 mA MIVNT 2 2.1 Ostwald [8, 9, 10]10 μL/min 1 1 2.2 cone-jetspray 10 kV 70 mm20±1 °C 10±5 % [11] [12] Rayleigh Coulomb Rayleigh Rayleigh Coulomb 2.3 0.1 g/L 100 nm2 g/L 200 nm 3 100 nm [] (References) [1] LIPINSKI C P. Poor aqueous solubility-an industry wide problem in drug discovery[J]. AmericanPharmaceutical Review, 2002, 5(3): 82-85. [2] ROSEN H, ABRIBAT T. The rise and rise of drug delivery[J]. Nature Reviews Drug Discovery, 2005, 4(5):381-385. [3] VAN-EERDENBRUGH B, VAN-DEN-MOOTER G, AUGUSTIJNS P. Top-down production of drugnanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products[J].International Jo