染料,药物和环境化学污染物与血清白蛋白的相互作用.pdfVIP

化学通报 2005 年 第68 卷 w141 染料、药物和环境化学污染物与血清白蛋白的相互作用 1,2 2 1* 于兵川 吴洪特 周培疆 (1 武汉大学资源与环境科学学院 武汉 430079 2 长江大学化学与环境工程学院 荆州 434025) 摘 要 血清白蛋白是血液中含量最丰富的蛋白质，具有许多重要的生理功能，能和许多化学物 质以不同方式结合，并携带这些物质通过血液在体内进行转运、运输、分配和代谢。本文综述了染料、 药物和环境化学污染物与血清白蛋白相互作用的研究进展，介绍了目前所研究的与血清白蛋白相互作 用的染料、药物和环境化学污染物种类及应用的方法，并提出了今后研究的工作重点。 关键词 血清白蛋白 染料 药物 环境化学污染物 相互作用 The Interaction of Dyes, Drugs and Environmental Chemical Pollutants with Serum Albumin 1,2 2 1* Yu Bingchuan , Wu Hongte , Zhou Peijiang 1 2 ( College of Resources and Environmental Sciences, Wuhan University, Wuhan 430079; College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou 434025) Abstract Serum albumin is the most abundant protein in blood, and it has many important physiological functions. Different kinds of chemical substances can be combined with serum albumin in different ways, and they are transported, distributed and metabolized in body through the blood. In the paper, the progress of the study on the interaction of dyes, drugs and environmental chemical pollutants with serum albumin was reviewed. The kinds of the dyes, drugs and environmental chemical pollutants, and the research method and purpose of their interacting with serum albumin were introduced. The key areas of the research in future investigation were proposed. Key words Serum albumin, Dyes, Drugs, Environmental chemical pollutants, Interaction 血清白蛋白是血液中含量最丰富的蛋白质。它由一条单独的氨基酸多肽链构成，