Team 5 ndash; Dr. Ross.ppt

Team 5 – Dr. Ross Chuan Xue David Tello Skyler Speakman Rina Santos Shilpa Das Gupta PURPOSE: Why? Small, dense LDL has been linked to coronary artery disease (CAD). We’d like to evaluate what measure to use: LDL itself, Apo-B/Apo-A1 Ratio, MR, C-Reactive Protein…and how prescribed drugs play a part in the process. What? Devise a mathematical model of LDL size distribution that is characterized by its components and processes. List of Chemical Players for the Model Components of LDL Components of HDL Team 5’s Initial Model involving ODE’s Team 5’s Initial Model involving ODE’s Team 5 – 2nd Model of LDL Delipidation Packard’s Diagram Team 5 – 2nd Model of LDL Delipidation Team 5 – 2nd Model of LDL Delipidation The Final Model Previous models required 3 objects to interact simultaneously. However, the probability for 3 particles to interact is much smaller than 2 particles. This lead us to disband the “swapping” ability of CETP for a more realistic series of reactions. Pool of CETP We introduced a pool (finite number) of CETP. CETP exists in 3 states: Free Carrying CE Carrying TG CETP serves as a transport for CE and TG between the lipoproteins (both HDL and LDL). There is no direct interaction between lipoproteins. Actions of CETP The aforementioned series of reactions can be broken down into 4 sub-reactions: CETP may pick up a CE or TG CETP may drop off a CE or TG Hepatic Lipase CETP accounts for all of the interactions involving CE and TG except Hepatic Lipase. Hepatic Lipase is a enzyme that takes TG from LDL. This process contributes to the formation of small dense LDL. Chemical Reactions: System of Differential Equations: System of Differential Equations: Numerical Approximations using MATLAB Increased CETP This allows for more exchanges between LDL. This is represented by the smoother graph on the right. Increased Hepatic Lipase This removes TG from LDL. The distribution has shifted towards less TG in LDL. Increased HDL source HDL removes CE from