Effectsofmelatoninonlipidperoxidationandantioxidant：对脂质过氧化和抗氧化褪黑激素的影响.pdfVIP

Asian J Androl 2006; 8 (5): 595–600 DOI: 10.1111/j.1745-7262.2006.00177.x . Original Article . Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis 1 2 2 1 1 2 Abdullah Armagan , Efkan Uz , H. Ramazan Yilmaz , Sedat Soyupek , Taylan Oksay , Nurten Ozcelik 1Department of Urology, 2Department of Medical Biology, Suleyman Demirel University, Faculty of Medicine, Isparta 32050, Turkey Abstract Aim: To examine the effects of melatonin treatment on lipid peroxidation (LPO) and the activities of antioxidant enzymes in the testicular tissue of streptozotocin (STZ)-induced diabetic rats. Methods: Twenty-six male rats were randomly divided into three groups as follows: group I, control, non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, melatonin-treated (dose of 10 mg/kg·day) diabetic rats (n = 9). Following 8-week melatonin treatment, all rats were anaesthetized and then were killed to remove testes from the scrotum. Results: As compared to group I, in rat testicular tissues of group II , increased levels of malondialdehyde (MDA) (P 0.01) and superoxide dismutase (SOD) (P 0.01) as well as decreased levels of catalase (CAT) (P 0.01) and glutathione peroxidase (GSH-Px) (P 0.05) were found. In contrast, as compared to group II, in rat testicular tissues of group III, levels of MDA decreased (but this decrease was not significant, P 0.05) and SOD (P 0.01) as well as CAT (P 0.05) increased. GSH-Px was not influenced by any of the treatment. Melatonin did not signifi- cantly affect the elevated gl