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Effectsoframiprilonventriculararrhythmiaafter:对室性心律失常的雷米普利的影响后.pdf
World J Emerg Med, Vol 5, No 2, 2014 135
Original Article
Effects of ramipril on ventricular arrhythmia after
myocardial infarction in rabbits
Ya Zhong, Ping Cao, Chuan-feng Tong, Xia Li
Department of Geratology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Corresponding Author: Ya Zhong, Email: zhya69@163.com
BACKGROUND: Ventricular arrhythmia (VA) is one of the most common complications of
myocardial infarction (MI), and ventricular tachycardia and fi brillation are the main causes for sudden
cardiac death. This study aimed to explore the effect of ramipril on the occurrence of VA and its
mechanism after MI in rabbits.
METHODS: Twenty-four New Zealand rabbits purchased from the Wuhan Laboratory Animal
Research Center were divided into three groups: sham-operated (SHAM) group (n=8), MI group (n=8)
and MI with ramipril (RAM) group (n=8). Rabbits in the SHAM group received a median sternotomy
without ligation of the left ventricular coronary artery. Rabbits in the MI and RAM groups received a
median sternotomy followed by ligation of the left coronary artery. The successful anterior MI was
confi rmed by elevation of the ST segment with more than 0.2 mV in lead II and III. After MI, rabbits
in the RAM group were fed with intragastric ramipril (1 mg/kg per day ) for 12 weeks. Before and 12
weeks after MI in the three groups, ventricular tachycardia or fi brillation (VT/VF) episodes and MAP
in cadiocytes of the epicardium, mid-myocardium and endocardium were recorded by a multichannel
physiograph. Students t test and ANOVA were used for statistical analysis.
RESULTS: VT/VF episodes were decreased more markedly in the RAM group than in the MI group
after 12 weeks (2.6±0.8 vs. 12.4±2.9, P0.05). Twelve
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