补阳还五汤预处理对MIRI家兔氧化指标的影响_李淑贞.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 09年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 M IRI 李淑贞, 崔茂香, 杨桂染, 杨艳梅 (, 061001) : 目的: 探讨补阳还五汤对心肌缺血再 注损伤的保护机制方法: 24只家兔随机分为 3 组:假手术 组模型对照组补阳还五汤组分别预处理 1周后, 结扎左冠状动脉前降支建立心肌缺血再 注损伤模型测 定各组心肌梗塞面积心电图 ST 段血清超氧化物歧化酶 ( SOD )丙二醛 (MDA) 的含量; 结果: 与模型对照组比 较, BHD组心肌梗塞范围ST 段上抬幅度及血清MDA含量明显降低(P 0. 01), 血清 SOD的活性显著升高(P 0. 01)结论:补阳还五汤可清除氧自由基, 减轻心肌缺血再 注损伤 :补阳还五汤; 缺血再 注; 氧化指标 : R2 5. 5 : A : 1673- 7717( 2009) 12- 2654- 03 Effect of Buyanghuanwu Decoction Pretreatment on Oxidative indexs ofM IRIRabbits L I Shu-zhen, CU IM ao-xiang, YANG Gu i-ran, YANG Yan-m ei ( Cangzhou M edical College, Cangzhou 061001, H ebei, China) Abstrac:t O bj ectiv e: To explore the protective mechan ism s of Buyanghuanwu decoction ( BHD) on M IR I. M ethods: The rabb itsw ere random ly divided into three groups : the sham group, them odel group, the BHD group. After pretrea- ting onew eek, to estab lish m odels ofm yocard ial ischem ia reperfusion injury by ligating the branch of left coronary artery. The size of myocardial infarct, the shape of ST segm ent in EGC, the contents of superoxided mi uase( SOD ), m alond ialde- hyde(MDA ) in serum of each group w ere detected. R esults: Compared w ith them odel group, the BHD group the size of myocardial infarct, the raising extent of ST segm ent, the contents of MDA in serum w ere sign ificantly decreased (P 0101), and the activity of SOD in serum w ere sign ificantly increased(P 0. 01). C onclus ion: BHD can clean oxyrad ical,