褪黑素对糖尿病并发症的干预作用及其机理.pdfVIP

圄匾囱坌鳖垡塑苤查!!盟生!旦箜!!鲞筮!塑丛!里』曼趔塑也丛!熊生!鱼塑!翌!Q盟!№!!!!盟!：! 褪黑素对糖尿病并发症的干预作用及其机理 卜乐 刘志民 【摘要】褪黑素对糖尿病并发症的干预作用表现在多方面、多环节。褪黑素能有效改善糖尿病 大鼠的肾小球硬化和小球内细胞增殖，有效抑制糖尿病大鼠肾脏氧化应激反应，改善肾功能；同时可 阻止低密度脂蛋白氧化，有效预防、控制1型糖尿病高血压的发生；通过抑制山梨醇的生成和一氧化 氮通路，减轻糖尿病神经病变的症状；阻止化学和紫外线诱导的白内障，对抗缺血诱导的视网膜色素 上皮细胞凋亡，亦可改善机体细胞免疫功能。褪黑素还有改善糖尿病患者骨代谢障碍等作用。因此， 褪黑素具有良好的临床应用前景。 【关键词】褪黑素；糖尿病并发症；氧化应激 Interventionandmechanismofmelatoninondiabetic BU complicationsLe，LIU of Zhi-min．Department Endocrinology，ChangzhengHospital，TheSecond删讹叫Medical 200003，China University，Shanghai researchoninterventionofmetatoninondiabetic hasmade 【Abstract】The greatprogress． complications MelatoninCall ameliorate sclerosisand indiabetic in— effectively domerul-eeU rat，and the—ome血【ar proliferation hibitoxidativeslIessin alsoblockstheoxidationoflow and theoccurrenceof kidney．It density lipoproteinprevents atherosclemsisand in 1 the ofD-sorbitoland thenitric hypertension typediabetes．Byreducingsynthesis blocking Vanrelievethe ofdiabetic more，it ealigo oxide-pathway，melatoninsymptom neuropathy．Furthermayprevent lentisinduced andultraviolet retinal induced bycompound rays，andfi出againstpignentepitheliumapoptosis by isehemia．Itisalsoableto eelldarimmune Call thebonemetabolism impmve function．Moreover，melatoninremidy disordersof hasa clinical diabetic．Accordingly，melatoninmay satisfactoryapplicationperspective． 【Keywords】Melatonin；Diabetic stress complications；Oxida