RasRafERK12信号通路表达上调损伤脊髓修复新希望.docVIP

Ras/Raf/ERK1/2信号通路表达上调：损伤脊髓修复的新希望？ 来自中国天津医科大学总医院冯世庆团队最新研究发现，Ras/Raf/ERK1/2信号通路参与了脊髓损伤后神经修复的过程，并在此过程中发挥重要的作用，具有诱导脊髓损伤后神经细胞凋亡的作用。该信号通路的新作用机制的发现为脊髓损伤后神经再生的研究提供了新的研究方向，并有可能解决脊髓损伤后神经再生障碍的难题。 Ras/Raf/ERK1/2信号通路是丝裂原活化蛋白激酶的家庭成员之一，在细胞信号转导网络中处于枢纽地位，是膜受体信号向细胞内传递的重要途径，通过调控细胞内的转录因子，参与细胞多种生理过程，如细胞生长、发育、分裂、死亡等。在以往研究中，该团队已证实脊髓损伤后Ras/Raf/ERK1/2信号通路被激活，但是其具体机制以往研究不透彻，此次研究更进一步深入研究了Ras/Raf/ERK1/2通路在脊髓损伤后的具体作用和对脊髓神经细胞的作用。 此次，他们公布一项出人意料的发现，Ras/Raf/ERK1/2信号通路确实参与到了脊髓损伤后修复的过程，并且发现磷酸化的ERK1/2显著的上调，该研究结果的发现将会对脊髓损伤后修复的研究提供新思路。其团队将此项研究成果的文章发表在《中国神经再生研究（英文版）》杂志2015年5月第5期。 脊髓损伤后7d时大鼠脊髓组织中磷酸化MEK1/2的免疫阳性反应增加 Article: Upregulated Ras/Raf/ERK1/2 signaling pathway: a new hope in the repair of spinal cord injury, by Tao Liu, Fu-jiang Cao, Dong-dong Xu, Yun-qiang Xu, Shi-qing Feng (Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin, China) Liu T, Cao FJ, Xu DD, Xu YQ, Feng SQ (2015) Upregulated Ras/Raf/ERK1/2 signaling pathway: a new hope in the repair of spinal cord injury. Neural Regen Res 10(5):792-796. 欲获更多资讯：请与《》联络；联络电话：，或用电子邮件联络：eic@ 。/ Association of up-regulated Ras/Raf/ERK1/2 signaling with spinal cord injury In a new study, Shiqing Feng`s group at Tianjin Medical University present an extremely novel finding that Ras/Raf/ERK1/2 signaling involved in the repairmen of spinal cord injury and disclosed the inhibition of the Raf signaling pathway can prevent spinal cord injury-induced neuron death. The spinal cord controls the sensor and motor system of our body, which has a limited ability regenerate after injury. Injury to the spinal cord may result a disastrous effect to our life in second, and the regenerative process of damaged spinal cord nerve is vey slow, which may take months to year for recovery. Understanding how the spinal cord develop and responses of the spinal cord induced by injury is important for us to create strategies for functional recovery. More and more studies reported that Ras/Raf/ERK1/2 signaling has a death-promoting apoptotic function