AMI患者血清NTProBNP与心肌酶水平的相关性研究.docVIP

AMI患者血清NT-ProBNP与心肌酶水平的相关性研究 　　作者：王爱萍　杨曙光　苏玉文　张代民　俞万泉　张杰 作者单位：1.泰山医学院附属泰安医院心内科，山东 泰安 271000; 　2.解放军第88医院，山东 泰安 271000 　　【摘要】目的 探讨急性心肌梗死(AMI)患者血清NT-ProBNP水平与心肌坏死标志物肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)的相关性，评价血清NT-ProBNP水平预测AMI患者的心肌梗死面积以及心功能状况。方法 入选初发AMI患者41例，正常对照39例，所有入选患者均于胸痛发作48～96 h抽取外周静脉血，用ELISA法检测血清NT-ProBNP水平，并常规检测CK和CK-MB，记录峰值浓度，同期测定患者左室射血分数(LVEF)。结果 AMI组NT-ProBNP水平明显高于正常对照组。在AMI组血清NT-ProBNP水平与心肌坏死标志物CK和CK-MB呈正相关。AMI组血清NT-ProBNP水平与LVEF呈负相关。结论 NT-ProBNP水平可反应心肌梗死面积的大小并初步评价左室功能。 　　【关键词】 急性心肌梗死　NT-proBNP　心肌酶　LVEF 　　The correlation between serum NT-ProBNP and cardiac creatine level in patients with acute myocardial infarction 　　WANG Ai-ping, YANG Shu-guang, SU Yu-wen, ZHANG Dai-min,YU Wan-quan, ZHANG Jie 　　1.Taian Central Hospital,Taian 271000,china; 　　2. The 88th Hospital of PLA,Taian 271000,China 　　Abstract : Objective： To discuss the correlation between serum NT-ProBNP and cardiac creatine level in patients with acute myocardial infarction(AMI).Methods: Serum NT-ProBNP concentrations and left ventricular ejection fraction(LVEF)) were measured in all patients . Serum CK and CK -MB level in the peripheral blood were also measured in patients with AMI. Results: Serum NT-ProBNP concentrations in patients with AMI were much higher than those in the health control people.There is significant correlation between serum NT-ProBNP and cardiac creatine level in AMI. A negative correlation between the plasma level of NT-ProBNP and LVEF was noted in the same group.Conclusions： In patients with AMI, increases in serum NT-ProBNP concentration during the early phase reflect MI size and LV function. 　　Key words: acute myocardial infarction; N-terminal Pro-B-type natriuretic peptide; creatine kinase and isoenzyme MB 　　氮末端脑钠素前体(NT-ProBNP)是体内脑钠素前体(ProBNP)裂解成脑钠素(BNP)时的中间产物。临床研究证实，在心功能不全患者中血浆NT-ProBNP浓度为BNP的4倍，比BNP更有利于监测心功能，判断预后[1]。血清NT-ProBNP水平与心肌坏死标志物的关系以及是否能作为心肌梗死面积的预测指标，目前仍不十分明确。我们检测入选患者血清NT-ProBNP水平，并与肌酸激酶和肌酸激酶同工酶(CK和CK-MB)以及左室射血分数(LVEF)等指标对比分析，旨在探讨NT-ProB