CK34_E12_p63表达在乳腺癌和前列腺癌诊断中的应用价值_胡志红.pdfVIP

2005 45 32 CK34βE12 、p63 1 2 3 ,　, 　 (1 九江学院医学院, 江西九江332000;2 九江学院附属医院;3 九江妇幼医院) 　　【】　　CK34βE12、p63 、。　 , CK34βE12、p63 、。　 CK34βE12 、,p63 、。 p63 ; p63 ;p63 , 。(PIN) CK34βE12 p63 , (), CK34βE12 ; PINCK34βE12、p63 ; 20 19 CK34βE12、p63 , 1 CK34βE12、p63 。　CK34βE12 ;p63 、, 。 【】　;;; 【】　R737　　【】　A 　　【】　1002-266X(2005)32-0010-03 Abstract:Objective:To eval ate the valve of CK34βE12, p63 imm nostaining in diagnosis of benign and malignant lesions of breast and prostate.Methods:Expression of CK34βE12, p63 in benign and malignant lesion of breast and prostate were observed by imm nohistochemical method.Res lts:Sensitivity and specifity of CK34βE12 expression inall benign and malignant lesions of breast was low,w hile p63 w as high.There was a contin o s layer of myoepithelial cells in the benign lesions of breast,they w ere reactive for p63.Myoepithelial layer was interr ptedly positive for p63 in carci- noma in sit .Myoepithelial layer was absent in invasive breast carcinoma.Contin o spositive expressions by CK34βE12 and p63 were fo nd in the acini and d cts of most benign prostatic hyperplasia and low prostatic intraepithelial neoplasia (PIN);Few cases showed interr pted expression, especially by CK34βE12 staining;Inter ped expression or negative re- action w as fo nd in highly PIN cases, CK34βE12 and p63 staining were negative in 19 o t of 20 prostatic carcinoma cas- es, 1 case presented focally positive reaction by CK34βE12 and p63.Concl sions:CK34βE12 is not an sef l antibody to label myoepithelial cells of breast.p63 is sensitive and specific in label myoepithelial cells of breast and basal cells of prostate, and helpf l to the diagnosis of breast carcinoma and prostate cancer. Key words:breast neopalsms;prostatic neoplasms;imm nohistochemistry;diagnosis 　　,