国产尼古丁舌下含片终止吸烟效果的随机双盲研究.pdfVIP

# 102# 2006 5 39 2 Chin J Psychiatry, M ay 2006, Vol. 39, N o. 2 # # 郭松 姜佐宁 孙洪强 牛光胜 高俊玉 杨晓辉 周东丰 = , 230( ; 2 mg /) , 115, 12; ([ 1/d)(\ 50% ) , ; , 5212% 1911% , 216% 1 1 8% , (P 01 01); 2~ 12CO (P 0101); 8 12 (P 0101) 12 , , , = ; ; , ; The smoking cessation efficacy of nicotine sublingual tablet: a double-blind, placebo-controlled trial * * GUO Song , JIAN G Zuo-ning, S UN H ong-q iang, et al1 Institute of M ental H ealth, P ek ing Universit (GUO Song is now atN ationalD rug D epend ence Treatm ent Cen ter, B eij ing A nding H osp italAff iliated Cap ital Un ivers it of M ed ical Sciences) , B eij ing 100083, China Corresp onding author: GUO Song, Emai:l guosong23@ 263 1net = Abstract Objective To evaluate the efficacy and safety of n icotine sub lingual tab let on sm ok ing cessation1Methods In the doub le-b lind, placebo-controlled study, 230 eligible sm okers w ere random ly given nicotine sub lingual tab let (2 m g/p ill) treatment ( n = 115 ) or placebo ( n = 115) 1 The sm okers in st th treatment group w ere prescribed hold ing the m axmi um of 15 to 20 p ills daily in the mouth from the 1 to th th w eek, then decreased progressively from the 5 w eek, and discontinued at the end of the 8 week1 A t the th end of 12 w eek, the sm oking abstinence rate, exp ired breath carbon m onoxide ( CO) level, urinary cotin ine concentration and s ide effects w ere compared1Results The rates of comp lete abstinen