NOD样受体在炎症反应中的调控作用.pdfVIP

第22 卷 第5 期 生命科学 Vol. 22, No. 5 20 10 年5 月 Chinese Bulletin of Life Sciences May , 20 10 文章编号：1004-0374(2010)05-0454-05 NOD 样受体在炎症反应中的调控作用 席　琼, 胡巢凤* （暨南大学医学院病理生理教研室, 广州 5 10632 ） 摘　要：天然免疫(innate immunity)是机体免疫系统直接抵御病原体入侵的最初阶段，通过机体自身的 特异性模式识别受体 (p attern -recognition receptors ，PRRs)来识别病原体特有的保守结构病原相关分子 模式 (p athogen-associated molecular patterns ，PAMPs) 。细胞内N OD 样受体(N LR s)是胞浆型PRRs 中 的一个重要家族，病原体侵袭细胞可上调其表达，启动机体的免疫应答和炎症反应，在机体天然免疫 应答中发挥独特的功能。最近有研究证明，N L R s 的突变与一些人类免疫性疾病相关，并且在细菌感 染和炎症反应的控制中起重要作用。该文将讨论N LR s 在炎症疾病中的调控作用。 关键词：N L R s ；炎症小体；炎症；调控 中图分类号：R392.11 文献标识码 A Regulation of N OD like receptors in the inflammation XI Qiong, HU Chao-feng* (Department of Pathophysiology , Jinan University Medical School, Guangzhou 510632, China) Abstract: The innate immune system is the first line of defense against microorganisms, and recognizes pathogens through pattern recognition receptors (PRRs) that detect conserved microbial component s called pathogen- associated molecular patterns (PAMPs). Nod-like receptors (NLRs) are an important family of intracellular pattern recognition receptors, which trigger immune and inflammatory responses after infection, playing a special role in innate immune system . Recently, some studies show that mutations in NLRs are associated with human immune diseases, and play an important role in infectious and inflammatory responses. In this review, we will discuss the regulation of NLRs in inflammation . Key words: NLRs ；inflammasome ；inflammation ; regulation NOD 样受体(NOD like receptors, NLRs)是一类 1　NLRs 的分类及信号转导 含有核苷酸结合寡聚域(nucleotide-binding oligomer-