氢化泼尼松治疗肾病综合征合并急性肾衰竭疗效分析.docVIP

氢化泼尼松治疗肾病综合征合并急性肾衰竭疗效分析 安徽省蚌埠医学院第一附属医院肾内科（233004） 陈卫东 常宝超 刘 磊 【摘要】目的 观察肾病综合征合并急性肾衰竭的临床特点，比较氢化泼尼松与地塞米松治疗肾病综合征合并急性肾衰竭疗效分析。方法 以2005年6月至2007年11月我院收治的肾病综合征合并急性肾衰竭患者为研究对象,共42例；其中2005年6月至2006年12月共22例为对照组，急性期采用地塞米松静滴治疗；2007年2月至2007年11月共20例为治疗组，急性期采用氢化泼尼松静滴治疗。结果 氢化泼尼松治疗组少尿期持续时间及肾功能恢复时间均少于地塞米松治疗组，消化道症状等不良反应较对照组轻。结论 氢化泼尼松治疗肾病综合征合并急性肾衰竭与地塞米松相比，疗效较好，可缩短少尿期及肾功能恢复时间。 【关键词】 肾病综合征；肾衰竭，急性；肾上腺皮质激素 Analysis of effects of Prednisolone on nephritic syndrome with acute renal failure. Chen Wei-dong，Chang bao-chao，Liu lei. Department of nephrology, the first affiliated hospital of Bengbu medical college, Anhui 233004 【Abstract】Objective To investigate the clinical characteristics of nephritic syndrome complicated with acute renal failure and to compare the effects of prednisolone with dexamethasone on the patietns with nephritic syndrome complicated with acute renal failure. Methods 42 patitents with nephritic syndrome complicated with acute renal failure were selected who were in our hospital from June, 2005 to November, 2007. They were divided into control group (n=22) who were in our hospital from June, 2005 to December, 2006 and treated with Dexamethasone and experiment group (n=20) who were in our hospital from February, 2007 to November, 2007 and treated with prednisolone. The therapeutic outcome of both groups were compared each other.Results There were significant difference in duration of oliguria stage and renal function recovery between the groups, the side-effects of digestive tract was lower in experiment patients. Conclusions The effect of prednisolone is better than dexamethasone on nephritic syndrome with acute renal failure, it can shorten the duration of oliguria stage and renal function recovery. 【Key words】 Nephritic syndrome; Renal failure, acute; Glucocorticosteroid 肾病综合征合并急性肾衰竭是肾病综合征诸多并发症中最为严重的一种,可发生于肾病综合征病程中任何阶段，甚至是首发症状，自1966年chamberlain 等首次报告以来，逐渐被重视。糖皮质激素应用是治疗肾病综合征合并急性肾衰竭的主要手段之一，近年我院住院肾病综合征合并急性肾衰竭42例，现我们对氢化泼尼松治疗肾病综合征合并急性肾衰竭疗效进行分析，报告如下。 1 资料与方法 1.1 临床资料