抗病毒天然免疫研究孙辉.pdfVIP

: 2013 43 10 : 815 ~ 823 SCIENTIA SINICA Vitae SCIENCE CHINA PRESS , * , , 100871 * , E-mail: jiangzf@ : 2013-09-03; : 2013-09-18 (:(: doi: 10.1360/052013-285 . , . : . T B . TLR , . RLH , NLR HIN200 . ERIS 20 90 , . , . , 4 : () Toll TLR(Toll like , , B receptor); () RIG-I(retinoic acid- inducible T gene 1)RLH(RIG- I-like helicase) . , ; () NLR(NOD-like receptor); () , ERIS(endoplasmic reticulum inter- feron stimulator) . DNA [3]. Lemaitre [1] Toll (Drosophila) , Poltorak [2] 1 TLR Toll . Toll . Toll . , Toll , , , , . , , TLR. , . , 13 Toll [4]. LRR(leucine-rich