Ubiquity of Lognormal Distributions in Intracellular Reaction Dynamic.pdfVIP

Ubiquity of Log-normal Distributions in 5 Intra-cellular Reaction Dynamics 0 0 2 r a M 1 5 2 1 9 Chikara Furusawa , Takao Suzuki , Akiko Kashiwagi , 2 1 2 3 4 5 3 4 5 Tetsuya Yomo , Kunihiko Kaneko ] N 1 Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, M . Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan o i 2 Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, b q- Suita, Osaka 565-0871, Japan [ 3 Graduate School of Frontier Biosciences, Osaka University 1-3 Yamadaoka, Suita, Osaka 565-0871, 1 v Japan 0 4 4 Department of Pure and Applied Sciences, Univ. of Tokyo Komaba, Meguro-ku, Tokyo 153-8902, 0 3 Japan 0 5 ERATO Complex Systems Biology Project, JST , 3-8-1 Komaba, Meguro-ku, 5 0 Tokyo 153-8902, Japan / o i b - q : v i X r a Corresponding Author: Kunihiko Kaneko Department of Pure and Applied Sciences, Univ. of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan Tel/FAX: +81-3-5454-6746 E-mail: kaneko@complex.c.u-tokyo.ac.jp 1 Abstract The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. First, the chemical abundances measured over many cells are found to obey a log- normal distribution and second, the relationship between the average and standard deviation of the abundances is found to be linear. The ubiquity of the laws is explored both theoretically and