胰高血糖素样肽1对胰腺β细胞的作用及其机制.pdfVIP

生 物 技 术 通 讯 LETTERSINBIOTECHNOLOGY Vol.26No.4 Jul.,2015 579 doi: 10.3969/j.issn.1009-0002.2015.04.029 综 述 胰高血糖素样肽1对胰腺β细胞的作用及其机制 1a,1b,2 1b 1a,1b 1b 1b 1a 宋晓艳 ，何文俊 ，孙晓雅 ，郝好杰 ，韩为东 ，母义明 1. 解放军总医院 a. 内分泌科；b. 基础医学所分子生物室；北京 100853； 2. 解放军总参谋部总医院 内分泌科，北京 100091 ［摘要］ 胰高血糖素样肽1（GLP-1）是一种主要由肠道L细胞分泌的肠促胰素。GLP-1能通过葡萄糖依赖模式刺激 胰岛素的分泌，同时有延缓胃排空、抑制胰高血糖素分泌、降低体重的作用，有利于维持体内血糖稳态。目前，基于 GLP-1的药物作为新的糖尿病治疗手段已越来越受到重视。我们简要综述GLP-1对胰腺β细胞的作用及机制研究 进展。 ［关键词］ 胰高血糖素样肽-1；β细胞；糖尿病 ［中图分类号］ R587.1 ［文献标识码］ A ［文章编号］ 1009-0002（2015）04-0579-04 Glucagon-Like Peptide-1 and Pancreatic β Cells 1a,1b,2 1a 1a,1b 1b 1b 1a SONGXiao-Yan ,HEWen-Jun ,SUNXiao-Ya ,HAOHao-Jie ,HANWei-Dong ,MUYi-Ming * 1. a. Department of Endocrinology; b. Molecular and Biological Laboratory; Chinese PLA General Hospital, Beijing 100853; 2. Department of Endocrinology, Chinese PLA 309 Hospital, Beijing 100091; China *Corresponding author, E-mail: muyiming@301 ［Abstract］ Glucagon-like peptide-1（GLP-1）is an incretin hormone released from intestinal L-cells in response to nutrients. GLP-1 stimulates insulin secretion from pancreatic β cells in a glucose-dependent manner. GLP-1 al⁃ so has many other beneficial effects for glucose homeostasis such as slowing gastric emptying, suppressing appe⁃ tite, reducing plasma glucagon, and stimulating glucose disposal. Therefore, there is increasing interest in incretin- based therapies for treatment of diabetes. In this review we discussed the current understanding of the effect of GLP-1 on pancreatic β cells. ［Key words］ glucagon-like peptide-1; pancreatic β cells; diabetes 糖尿病已成为全球性的公共卫生问题，据估计， GLP-1还能通过促进β细胞增殖、再生并抑制其凋