埃索美拉唑联合伊托必利治疗咽喉反流性疾病及食管动力学分析.pdfVIP

CHIN ARCH OTOLARYNGOL HEAD NECK SURG / September 2015, Vol.22, No.9 445 DOI: 10.16066/j.1672-7002.2015.09.004 咽喉反流专题：论著 埃索美拉唑联合伊托必利治疗咽喉反流性疾病及食管动力学分析 1 1 2 1 刘凡理 ，陈波蓓，陈小燕，倪丽艳 温州医科大学附属第二医院 1 耳鼻咽喉科，2 消化内科，浙江　温州　325000 [摘　要]　目的　通过埃索美拉唑联合伊托必利诊断 [ABSTRACT]　OBJECTIVE　To study the changes of 性治疗，观察咽喉反流性疾病（laryngopharyngeal reflux symptoms, signs and esophageal dynamics characteristics of disease ，LPRD ）患者在治疗前后反流症状体征的变化及 laryngopharyngeal reflux diseases(LPRD) before and after 食管动力学特点。 　将疑似LPRD患者进行诊断性治 treatment with esomeprazole and itopride. METHODS 方法 疗，治疗前后均行反流体征评分量表（reflux finding score ， The suspected LPRD patients were took the diagnostic RFS ）和反流症状指数量表（reflux symptom index ，RSI ） treatment with esomeprazole and itopride. Reflux finding 的评分及高分辨率食管测压（high resolusion manometry， score(RFS), reflux symptoms index(RSI) score and high- HRM ）检测。按胃食管反流病（gastroesophageal reflux resolution esophageal pressure were evaluated before and after disease ，GERD）问卷评分标准，分为单纯LPRD组和LPRD treatment. The patients were divided into pure LPRD group 伴GERD组。 　确诊为LPRD患者38例，单纯LPRD组 and LPRD with GERD group according to gastroesophageal 结果 12例，LPRD伴GERD组26例。两组中患者年龄、性别构成 reflux disease(GERD) questionnaire scores. RESULTS 比、BMI等差异均无统计学意义。单纯LPRD组RSI评分 There were 38 patients confirmed with LPRD(pure LPRD Z =-3.009，P ＜0.05 ），RFS 在治疗前后差异有统计学意义（ group:12 cases, LPRD with GERD group:26 cases). The BMI, 评分在治疗前后差异无统计学意义（Z =-0.976 ，P ＞0.05）， age, gender ratio had no statistical difference between the two LPRD伴GERD组RSI和RFS评分在治疗前后差异均有统计 groups(P 0.05). In LPRD group, RSI had significant difference 学意义（P ＜0.05）。单纯LPRD组治疗前后食管动力变化差 before and after tre