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《New players in the regulation of ecdysone biosynthesis》.pdf
Availableonlineatwww.
JOURNAL0晒
·乏;,ScienceDirect
GE】ⅫDⅫCS
叠一
New inthe of biosynthesis
playersregulationecdysone
b’8
Xun T.Warren I.Gilbert
a’_,James b,Lawrence
Huang
8 and and
LaboratoryofMolecularDevelopmentalBiology,InstituteofGenetics
Biology,ChineseAcademyofSciences,Beijing100101,China
Developmental
6 Carolinaat HillNC
Hill 27599—3280,USA
DepartmentofBiology,UniversityofNonh ChapelChapel
November 24November2007
Receivedfor 20November 24
publicafion 2007;revised 2007;accepted
Abstract
hormone transitions.suchas and of
Insect steroid
ecdysone regulatesmajordevelopmental moltingmetamorphosis.Theproduction
with ofthese outhowthe is iscrucialto
correlateswell the
ecd37sone timing transitions.Findingecdysonebiosynthesisregulated fully
understandthese switches.Herewesummarizedrecent inthe of
sophisticateddevelopmental findingsregulationecdysone
fromthe ofcell andsubstratecholesterol
aspecm signaling,keybiosyntheticenzymes
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