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6 纳米技术应用.ppt 115页

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5-Aza-CdR对人食管癌细胞株生物学行为及TFPI-2 mRNA表达的影响 目前,国外以TFPI-2为药物研究靶点,就TFPI-2在肿瘤治疗、肿瘤临床诊断、促进伤口愈合和动脉粥样硬化治疗等领域中的应用,也正在进行广泛深入的研究。本研究用甲基转移酶抑制剂5-Aza-CdR处理人食管癌Eca9706细胞株,检测TFPI-2基因表达的变化及其对细胞增殖和凋亡的影响,以期寻找治疗肿瘤的新靶点。 【参考文献】 [1]HUBE F, REBERDIAU P, IOCHMANN S, et al. Characterization and functional analysis of TFPI-2 gene promoter in a human choriocarcinoma cell line [J]. Thromb Res, 203, 109(4):207-215. [2]MIYAGIi Y, KOSHIKAWA N, YASUMITSU H, et al. cDNA cloning and mRNA expression of a serine protein 5 and tissue factor pathway inhibitor-2 [J]. J Biochem, 1994, 116(5):939-942. [3]RAO CN, SEGAWA T, NAVARI JR, et al. Methylation of TFPI-2 gene is not the sole cause of its silencing [J]. Int J Oncol, 2003, 22(4):843-848. [4]KONDURI SD, SRIVENUGOPAL KS, YANAMANDRA N, et al. Promoter methyl and silencing of the tissue factor pathway inhibitor-2(TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells [J]. Oncogene, 2003, 22(29):4509-416. [5]STEINER FA, HONG JA, FISCHETTE MR, et al. Sequential5-Aza-2-deoxycytidi- ne/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2(TFPI-2) expression in cancer cells [J]. Oncogene, 2005, 24(14):2386-2397. [6]HERMAN JG, BAYLIN SB. Promoter-region hypermethylation and gene silencing in human cancer [J]. Curr Top Microbiol Immunol, 2000, 249:35-54. [7]JONES PA, BAYLIN SB. The fundamental role of epigenetic events in cancer [J]. Nat Rev Genet, 2002, 3(6):415-428. [8]EHRLICH M. DNA methylation in cancer: too much, but also too little [J]. Oncogene, 2002, 21(35):5400-5413. [9]PAZ MF, FRAGA MF, AVILA S, et al. A systematic profile of DNA methylation in human cancer cell lines [J]. Cancer Res, 2003, 63(5):1114-1121. [10]MIZUNO S, CHIJIWA T, OKAMURA T, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia [J]. Blood, 2001, 97(5):1172-1179. [11]BENDER CM, PAO MM, JONES PA. Inhibition of

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