提高皮肤光透明作用地物化方法研究.pdf

在体人体(in vivo)实验中，OCT成像深度及分辨率在处理30分钟后显著提高， 其成像深度从1．4毫米增加到2毫米，且在组织深层处探测到真皮层的血管。本 实验首次证明了超声波实现活体人体皮肤光学透明过程中的能力，提高了皮肤光 透明的效率和速率。 本论文还研究了渗透促进剂和超声波导入法联合辅助实现皮肤组织光透明， 将光透明剂、渗透促进剂和超声波导入法三者有机结合，提高了光透明剂进入完 整皮肤的能力，并用光相干断层成像技术研究了不同组合方法对皮肤光学成像效 果的影响。实现了增强活体皮肤光透深度，改进光相干断层成像深度和对比度的 目的。 关键词：光透明剂，渗透促进剂，超声波，近红外光谱，光相干断层成像(OCT) II Skin enhancementwithchemicalenhancers optical clearing andUltrasound Abstract Photonic inmedical andtreatmentisthecurrent technology imaging，diagnosis internationalofresearch．Themain factoristhe of hot。spots limiting lightscattering tissuethatrestricts the to the the light of biological penetratedepthtissue，limiting of the scopeapplication,reducing optical(microscopic)imagingdepth，resolution， andthe contrastratio oflasertreatment．At efficiency present，therapiddevelopment of non—invasive detectionandlaser highlypromising opticaltechniques treatment need reachthe ofthe to the light requireddepth biologicaltissue，howimproveability of tissue of light penetration(biologicalopticalclearing)isgreatsignificance．The ofselectivetranslucenceofthe skin possibility superficiallayers(skinoptical clearing) in is useful functional very developing imagingtechniques，includingoptical coherence